Echocardiography and pulmonary function as screening tests for pulmonary arterial hypertension in systemic sclerosis

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Echocardiography and pulmonary function as screening tests for pulmonary arterial hypertension in systemic sclerosis.

OBJECTIVE A prospective study to evaluate echocardiography and gas transfer (DLCO) by comparison with cardiac catheterization in discriminating between patients with and without systemic sclerosis-associated pulmonary arterial hypertension (SScPAH). METHOD A total of 137 (52 with and 85 without pulmonary fibrosis) had echocardiography and lung function tests within 3 months of their definitiv...

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Screening for pulmonary arterial hypertension in systemic sclerosis.

The onset and progression of pulmonary arterial hypertension (PAH) in patients with systemic sclerosis (SSc) can be particularly aggressive; however, effective treatments are available. Therefore, early identification of patients with suspected PAH, confirmation of diagnosis, and intervention is essential. PAH may be challenging to diagnose in its earliest stages, particularly in populations th...

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Pulmonary arterial hypertension in systemic sclerosis.

Pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc) is a complex clinical situation resulting from restricted flow through the pulmonary arterial circulation ending in increased pulmonary vascular resistance and right heart failure. PAH is a common and life-threatening complication in connective tissue diseases, specifically in SSc if not treated rapidly and adequately. Based on t...

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The heart and pulmonary arterial hypertension in systemic sclerosis.

Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterized by vasculopathy and progressive fibrosis of the skin and visceral organs (gastrointestinal tract, heart, kidneys and lungs). Although the prevalence is low, SSc is a disease with high morbidity and mortality. Since pulmonary arterial hypertension (PAH) associated with SSc (SSc-PAH) and clinically evident cardiac i...

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D-dimer and pulmonary arterial hypertension in systemic sclerosis.

BACKGROUND Micro-vascular thrombus is a common pathological finding in pulmonary artery hypertension. The association between plasma D-dimer, a marker of thrombus formation, and pulmonary artery hypertension (PAH) in patients with systemic sclerosis is unknown. OBJECTIVE To assess the correlation of the level of plasma D-dimer and pulmonary artery pressure in patients with systemic sclerosis....

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ژورنال

عنوان ژورنال: Rheumatology

سال: 2004

ISSN: 1460-2172

DOI: 10.1093/rheumatology/keh067